Randevu Al
Tissue Typing and Transplantation Immunology is a highly specialized laboratory discipline that evaluates immunological compatibility between donor and recipient in cell, tissue, and organ transplantation. Transplant success largely depends on the accurate and reliable determination of this compatibility.
Our laboratory plays a critical role in bone marrow (hematopoietic stem cell) transplantation and in the diagnosis and follow-up of hematologic malignancies and primary immunodeficiency disorders. With modern infrastructure and an experienced team, we provide comprehensive scientific support to clinical departments.
The HLA system is a fundamental component of the immune system, enabling the distinction between “self” and “non-self.” Evaluating HLA compatibility prior to transplantation is essential for preventing rejection and ensuring long-term success.
HLA tissue typing is performed for:
This process enables identification of the most suitable donor.
All analyses are conducted at the DNA level.
If a suitable donor cannot be identified through low-resolution typing, high-resolution analyses are performed through accredited external laboratories to ensure uninterrupted transplantation processes.
Flow cytometry allows simultaneous analysis of cellular surface and cytoplasmic markers and is indispensable in hematologic malignancy diagnosis and follow-up.
Applications include:
Approximately 40 immunophenotypic panels are utilized to provide patient-specific analyses.
In leukemia patients, detection of minimal residual disease after treatment is critical for evaluating prognosis and relapse risk.
Our laboratory performs:
MRD assessment guides treatment response evaluation and therapeutic decision-making.
Flow cytometric analyses evaluate:
When indicated, naïve and memory T-cell populations are assessed in detail.
During bone marrow transplantation, apheresis products are analyzed to determine:
These data assist clinical teams in optimizing transplantation timing and outcomes.
Our laboratory delivers accurate, rapid, and reliable results for transplantation and hematologic disease management. With high-quality standards, advanced technologies, and experienced specialists, we provide comprehensive support for complex immunologic evaluations.